Iduna Fichtner Selected Research

Jet Injections

5/2014	Preclinical study on combined chemo- and nonviral gene therapy for sensitization of melanoma using a human TNF-alpha expressing MIDGE DNA vector.
1/2009	Nonviral jet-injection technology for intratumoral in vivo gene transfer of naked DNA.
1/2008	Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA.
12/2005	Nonviral jet-injection gene transfer for efficient in vivo cytosine deaminase suicide gene therapy of colon carcinoma.
4/2005	Use of the nuclease inhibitor aurintricarboxylic acid (ATA) for improved non-viral intratumoral in vivo gene transfer by jet-injection.
10/2004	Low-volume jet injection for efficient nonviral in vivo gene transfer.

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Iduna Fichtner Research Topics

Disease

62	Neoplasms (Cancer) 01/2021 - 02/2002
20	Neoplasm Metastasis (Metastasis) 10/2016 - 01/2002
18	Breast Neoplasms (Breast Cancer) 01/2018 - 02/2002
18	Carcinoma (Carcinomatosis) 10/2010 - 02/2002
9	Colonic Neoplasms (Colon Cancer) 01/2018 - 01/2005
8	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018 - 07/2008
7	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 07/2009
6	Melanoma (Melanoma, Malignant) 05/2014 - 07/2003
5	Lung Neoplasms (Lung Cancer) 12/2015 - 07/2008
5	Leukemia 07/2014 - 05/2003
4	Brain Neoplasms (Brain Tumor) 01/2016 - 04/2009
4	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 07/2014 - 09/2006
3	Carcinogenesis 01/2018 - 01/2005
2	Sarcoma (Soft Tissue Sarcoma) 01/2021 - 06/2011
2	Squamous Cell Carcinoma of Head and Neck 01/2017 - 06/2015
2	Head and Neck Neoplasms (Head and Neck Cancer) 01/2017 - 06/2015
2	Glioblastoma (Glioblastoma Multiforme) 01/2014 - 04/2009
2	Neuroblastoma 12/2013 - 02/2006
2	Body Weight (Weight, Body) 01/2013 - 01/2009
2	Hyperthermia 10/2010 - 01/2007
2	Multiple Myeloma 09/2006 - 02/2006
2	Bites and Stings (Sting) 07/2006 - 04/2005
1	Glioma (Gliomas) 05/2018
1	Squamous Cell Neoplasms (Squamous Cell Cancer) 01/2017
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 11/2016
1	Leukopenia 01/2016
1	Thrombocytopenia (Thrombopenia) 01/2016
1	Adenocarcinoma 11/2014

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 01/2018 - 02/2002
15	Pharmaceutical PreparationsIBA 01/2016 - 12/2002
13	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2014 - 12/2002
11	Liposomes (Liposome)IBA 01/2016 - 01/2002
11	ProdrugsIBA 09/2012 - 02/2002
8	Messenger RNA (mRNA)IBA 09/2011 - 09/2004
7	DNA (Deoxyribonucleic Acid)IBA 05/2014 - 06/2002
6	Tamoxifen FDA LinkGeneric 01/2018 - 08/2004
6	Peptides (Polypeptides)IBA 11/2014 - 05/2007
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 10/2008
5	Epithelial Cell Adhesion MoleculeIBA 01/2011 - 04/2005
5	AlbuminsIBA 07/2009 - 12/2002
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2014 - 06/2002
4	Small Interfering RNA (siRNA)IBA 01/2014 - 01/2008
3	Cisplatin (Platino)FDA LinkGeneric 01/2018 - 03/2006
3	CateninsIBA 10/2016 - 02/2011
3	CaspasesIBA 01/2014 - 10/2007
3	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 07/2011 - 05/2003
3	AcidsIBA 05/2011 - 12/2002
3	Cathepsin BIBA 07/2009 - 05/2007
3	Antineoplastic Agents (Antineoplastics)IBA 04/2009 - 09/2004
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2021 - 11/2014
2	Cetuximab (Erbitux)FDA Link 01/2021 - 01/2017
2	Carboplatin (JM8)FDA LinkGeneric 01/2018 - 10/2008
2	Methadone (Dolophine)FDA LinkGeneric 01/2014 - 05/2013
2	Opioid Receptors (Opioid Receptor)IBA 01/2014 - 05/2013
2	Bortezomib (Velcade)FDA Link 03/2013 - 02/2006
2	Folic Acid (Vitamin M)FDA LinkGeneric 09/2012 - 03/2011
2	EnzymesIBA 08/2012 - 01/2011
2	Indicators and Reagents (Reagents)IBA 08/2012 - 01/2009
2	Calcium-Binding ProteinsIBA 09/2011 - 07/2011
2	SolventsIBA 07/2011 - 03/2006
2	multidrug resistance-associated protein 1IBA 07/2011 - 05/2003
2	Gemcitabine FDA Link 06/2011 - 10/2008
2	Cytosine DeaminaseIBA 10/2010 - 12/2005
2	sagopiloneIBA 03/2010 - 04/2009
2	Epothilones (Epothilone)IBA 03/2010 - 04/2009
2	Paclitaxel (Taxol)FDA LinkGeneric 04/2009 - 10/2008
2	LipidsIBA 03/2009 - 04/2003
2	Matrix Metalloproteinases (MMPs)IBA 07/2008 - 07/2003
2	alanylphenylalanine (Ala-Phe)IBA 11/2007 - 08/2007
2	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 11/2007 - 05/2007
2	Estrogen Receptor Modulators (Antiestrogen)IBA 10/2007 - 10/2004
2	Peptide Hydrolases (Proteases)FDA Link 08/2007 - 05/2007
2	Sulfhydryl Compounds (Thiols)IBA 05/2007 - 12/2002
2	Flucytosine (Ancobon)FDA Link 12/2005 - 04/2003
2	beta-Galactosidase (Lactaid)IBA 10/2004 - 06/2002
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 09/2004 - 02/2002
1	ChromatinIBA 05/2018
1	Terminator Codon (Termination Codon)IBA 01/2018
1	Fulvestrant (Faslodex)FDA Link 01/2018
1	Phosphotransferases (Kinase)IBA 01/2018
1	Tyrosine (L-Tyrosine)FDA Link 01/2018
1	PlatinumIBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2017
1	Protein Kinases (Protein Kinase)IBA 11/2016
1	regorafenibIBA 11/2016
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2016
1	Therapeutic UsesIBA 01/2016
1	Volatile Organic CompoundsIBA 12/2015
1	Everolimus FDA Link 06/2015
1	AMP-Activated Protein KinasesIBA 11/2014
1	Tyrosine Kinase InhibitorsIBA 11/2014
1	GlucocorticoidsIBA 07/2014
1	Dexamethasone (Maxidex)FDA LinkGeneric 07/2014

Therapy/Procedure

17	Therapeutics 01/2021 - 04/2003
7	Drug Therapy (Chemotherapy) 03/2013 - 12/2002
6	Jet Injections 05/2014 - 10/2004
2	Transplantation 01/2011 - 10/2005
2	Intravenous Administration 03/2009 - 12/2002
2	Injections 07/2006 - 04/2005
1	Precision Medicine 01/2021